eGFR · CKD-EPI 2021
UACR Category
Kidney Failure Risk · Tangri 2016 (KFRE)
Clinical Disclaimer: This tool is not a substitute for professional medical judgment.
eGFR uses the race-free CKD-EPI 2021 creatinine equation. Kidney failure risk uses the
4-variable KFRE (Tangri et al., JAMA 2016):
βsum = −0.2201×(age/10−7.036) + 0.2467×(male−0.5642)
−0.5567×(eGFR/5−7.222) + 0.4510×(ln[ACR]−5.137)
Risk = 1−S₀exp(βsum), where S₀ = 0.9832 (2-yr)
and 0.9365 (5-yr) for North American cohorts.
Validated for eGFR 15–59 mL/min/1.73 m²; interpret with caution outside this range.
References
1. Inker LA et al. CKD-EPI 2021. NEJM 2021;385:1737–1749.
2. Tangri N et al. KFRE. JAMA 2016;315:164–174.
3. KDIGO 2024 CKD Guidelines.